On our way back from having ayam goreng, Ummu dropped the Pepsi can and it dented. Keep in my that I really didn't know at that time (on CNY weekend) why that 'don't consume if the can is dented' exists.
BUT,, as i'm now studying for my synaptic transmission exam tomorrow, apparently the disease mechanism of tetanus and botulism helps established the currently hold hypothesis of Vesicular Theory of Release!
If you consumed the food in dented can, you can get Botulism from the toxin from botulinum toxin. So far, we know Bot A up to G. They just discovered a new one; Bot H. But worry you not, this disease is veeeeery rare.
How the disease works is the bacterium will interrupt with the proteins believed to be crucial for regulating the neurotransmitter vesicle fusion for release. Those proteins are VAMP, SNAP-25, and syntaxin. These three proteins form a Core complex or SNARE proteins, which are believed to be formed during Docking stage. There are 6 stages of the Vesicular Theory of Release; Transport, Targeting, Tethering, Docking, Priming, and Fusion. If you can't dock the vesicle, how are you gonna allow for release right?
These botulinum toxins, as the experiment showed, cleaved the three proteins which are supposed to be bound to each other, interrupting the whole cascade.
So yeah. Turned out I just had a casual conversation with Ummu, before she went to sleep, about Botulism and Tetanus. I go, "Ummu ingat tak yang aku tanya boleh consume tak pepsi tu kalau kemik sebab jatuh? Ha ini jawapannya."
No comments:
Post a Comment